| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S2MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ERBB3 |
| Gene ID: | 2065 |
| Uniprot ID: | ERBB3_HUMAN |
| Specificity: | A synthetic phosphorylated peptide around Y1222 of human ERBB3 (P21860). |
| Immunogen Sequence: | LGYEY |
| Tissue Specificity | Epithelial tissues and brain. |
| Post Translational Modifications | Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. |
| Function | Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it.ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation. |
| Protein Name | Receptor Tyrosine-Protein Kinase Erbb-3 Proto-Oncogene-Like Protein C-Erbb-3 Tyrosine Kinase-Type Cell Surface Receptor Her3 |
| Database Links | Reactome: R-HSA-1227986 P21860-1 Reactome: R-HSA-1236394 P21860-1 Reactome: R-HSA-1250196 P21860-1 Reactome: R-HSA-1257604 P21860-1 Reactome: R-HSA-1306955 P21860-1 Reactome: R-HSA-1358803 P21860-1 Reactome: R-HSA-1963642 P21860-1 Reactome: R-HSA-2219530 P21860-1 Reactome: R-HSA-5673001 P21860-1 Reactome: R-HSA-6785631 P21860-1 Reactome: R-HSA-6811558 P21860-1 Reactome: R-HSA-8847993 P21860-1 Reactome: R-HSA-8863795 P21860-1 Reactome: R-HSA-9664565 P21860-1 Reactome: R-HSA-9665686 P21860-1 |
| Cellular Localisation | Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Secreted |
| Alternative Antibody Names | Anti-Receptor Tyrosine-Protein Kinase Erbb-3 antibody Anti-Proto-Oncogene-Like Protein C-Erbb-3 antibody Anti-Tyrosine Kinase-Type Cell Surface Receptor Her3 antibody Anti-ERBB3 antibody Anti-HER3 antibody |
Information sourced from Uniprot.org