| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-Ephrin type-A receptor 3 and Ephrin type-A receptor 4 and Ephrin type-A receptor 5-Tyr779/833 (746-795 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
EPHA3EPHA5204220442043EPHA3_HUMANEPHA5_HUMANEPHA4_HUMAN |
| Immunogen Region: |
746-795 aa |
| Specificity: |
Phospho-EphA3/4/5 (Y779/833) Polyclonal Antibody detects endogenous levels of EphA3/4/5 protein only when phosphorylated at Y779/833. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human EPHA3/4/5 around the phosphorylation site of Tyr779/833 at the amino acid range 746-795 |
| Post Translational Modifications | Autophosphorylates upon activation by EFNA5. Phosphorylation on Tyr-602 mediates interaction with NCK1. Dephosphorylated by PTPN1. |
| Function | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development. |
| Protein Name | Ephrin Type-A Receptor 3Eph-Like Kinase 4Ek4Hek4HekHuman Embryo KinaseTyrosine-Protein Kinase Tyro4Tyrosine-Protein Kinase Receptor Etk1Eph-Like Tyrosine Kinase 1 |
| Database Links | Reactome: R-HSA-2682334Reactome: R-HSA-3928663Reactome: R-HSA-3928665 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Ephrin Type-A Receptor 3 antibodyAnti-Eph-Like Kinase 4 antibodyAnti-Ek4 antibodyAnti-Hek4 antibodyAnti-Hek antibodyAnti-Human Embryo Kinase antibodyAnti-Tyrosine-Protein Kinase Tyro4 antibodyAnti-Tyrosine-Protein Kinase Receptor Etk1 antibodyAnti-Eph-Like Tyrosine Kinase 1 antibodyAnti-EPHA3 antibodyAnti-ETK antibodyAnti-ETK1 antibodyAnti-HEK antibodyAnti-TYRO4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
