• Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).
  • Western Blot analysis of 1 Hela treated with LPS, 2 Hela, using primary antibody at 1:1000 dilution. Secondary antibody (STJS000791) was diluted at 1:10000

Anti-Phospho-EPHA1-Tyr605 antibody (STJ193209)

SKU:
STJ193209

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Ephrin type-A receptor 1-Tyr605 is suitable for use in Immunohistochemistry, Immunofluorescence and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-200
WB 1:500-2000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EPHA1
Gene ID: 2041
Uniprot ID: EPHA1_HUMAN
Specificity: This antibody detects endogenous phospho levels of EPHA1 (Phospho-Tyr605) at Human:Y605, Mouse:Y606
Immunogen: Synthesized peptide derived from the human EPHA1 (Phospho-Tyr605)
Post Translational Modifications Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1. Ubiquitinated.
Function Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
Protein Name Ephrin Type-A Receptor 1
Hepha1
Eph Tyrosine Kinase
Eph Tyrosine Kinase 1
Erythropoietin-Producing Hepatoma Receptor
Tyrosine-Protein Kinase Receptor Eph
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-2892247
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Ephrin Type-A Receptor 1 antibody
Anti-Hepha1 antibody
Anti-Eph Tyrosine Kinase antibody
Anti-Eph Tyrosine Kinase 1 antibody
Anti-Erythropoietin-Producing Hepatoma Receptor antibody
Anti-Tyrosine-Protein Kinase Receptor Eph antibody
Anti-EPHA1 antibody
Anti-EPH antibody
Anti-EPHT antibody
Anti-EPHT1 antibody

Information sourced from Uniprot.org

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