• Western Blot analysis of 1 HeLa cell, 2, LPS 100ng/mL 30min treated, using primary antibody at 1:1000 dilution. Secondary antibody (STJS000791) was diluted at 1:10000

Anti-Phospho-DUSP16-Ser446 antibody (STJA0009999)

SKU:
STJA0009999

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Dual specificity protein phosphatase 16-Ser446 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DUSP16
Gene ID: 80824
Uniprot ID: DUS16_HUMAN
Specificity: This antibody detects endogenous levels of MKP-7 (Phospho-Ser446) at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human MKP-7 (Phospho-Ser446)
Post Translational Modifications Phosphorylated at Ser-446 by MAPK1/ERK2, which prevents its degradation, and thereby stabilizes it and blocks JNK MAPK activity. (Microbial infection) Acetylated at Lys-55 by the M.tuberculosis Eis protein.this leads to the inhibition of JNK-dependent autophagy, phagosome maturation, and ROS (reactive oxygen species) generation for enhanced intracellular survival of M.tuberculosis.
Function Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
Protein Name Dual Specificity Protein Phosphatase 16
Mitogen-Activated Protein Kinase Phosphatase 7
Map Kinase Phosphatase 7
Mkp-7
Database Links Reactome: R-HSA-112409
Reactome: R-HSA-5675221
Reactome: R-HSA-9636569
Reactome: R-HSA-9652817
Cellular Localisation Cytoplasm
Nucleus
Cytoplasmic Vesicle
After Dissociation Upon Agtr Stimulation
Re-Associates With Arrb2 On Endocytic Vesicles
Alternative Antibody Names Anti-Dual Specificity Protein Phosphatase 16 antibody
Anti-Mitogen-Activated Protein Kinase Phosphatase 7 antibody
Anti-Map Kinase Phosphatase 7 antibody
Anti-Mkp-7 antibody
Anti-DUSP16 antibody
Anti-KIAA1700 antibody
Anti-MKP7 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance