Anti-Phospho-DSP-Ser165/166 antibody (STJ196285)

SKU:
STJ196285

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Desmoplakin-Ser165/166 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DSP
Gene ID: 1832
Uniprot ID: DESP_HUMAN
Specificity: This antibody detects endogenous levels of Human Mouse Rat Desmoplakin (phospho-Ser165 or 166)
Immunogen: Synthesized phosho peptide around human Desmoplakin (Ser165 and 166)
Function Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance.
Protein Name Desmoplakin
Dp
250/210 Kda Paraneoplastic Pemphigus Antigen
Database Links Reactome: R-HSA-351906
Reactome: R-HSA-6798695
Reactome: R-HSA-6805567
Reactome: R-HSA-6809371
Reactome: R-HSA-9696264
Reactome: R-HSA-9696273
Cellular Localisation Cell Junction
Desmosome
Cell Membrane
Cytoplasm
Localizes To Desmosome Precursor Particles In The Cytoplasm
Localizes To The Cytoplasm In Undifferentiated Keratinocytes However Becomes Localizes To Both Lateral And Tricellular Cell-Cell Contacts As Differentiation Progresses And As Epithelial Sheet Formation Completes
Alternative Antibody Names Anti-Desmoplakin antibody
Anti-Dp antibody
Anti-250/210 Kda Paraneoplastic Pemphigus Antigen antibody
Anti-DSP antibody

Information sourced from Uniprot.org

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