| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Phospho-Cyclic AMP-responsive element-binding protein 1-Ser121 (91-140 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CREB1 |
| Gene ID: | 1385 |
| Uniprot ID: | CREB1_HUMAN |
| Immunogen Region: | 91-140 aa |
| Specificity: | Phospho-CREB-1 (S121) Polyclonal Antibody detects endogenous levels of CREB-1 protein only when phosphorylated at S121. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CREB around the phosphorylation site of Ser121 at the amino acid range 91-140 |
| Function | Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells. Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signaling. |
| Protein Name | Cyclic Amp-Responsive Element-Binding Protein 1Creb-1Camp-Responsive Element-Binding Protein 1 |
| Database Links | Reactome: R-HSA-111931Reactome: R-HSA-111932Reactome: R-HSA-198693Reactome: R-HSA-199920Reactome: R-HSA-2151201Reactome: R-HSA-2197563Reactome: R-HSA-375165Reactome: R-HSA-400253Reactome: R-HSA-442720Reactome: R-HSA-442729Reactome: R-HSA-442742Reactome: R-HSA-5674400Reactome: R-HSA-881907Reactome: R-HSA-9022692Reactome: R-HSA-9022699Reactome: R-HSA-9022702Reactome: R-HSA-9022707Reactome: R-HSA-9031628Reactome: R-HSA-9609690Reactome: R-HSA-9616222Reactome: R-HSA-9634638Reactome: R-HSA-9660821Reactome: R-HSA-9664323Reactome: R-HSA-9707616 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Cyclic Amp-Responsive Element-Binding Protein 1 antibodyAnti-Creb-1 antibodyAnti-Camp-Responsive Element-Binding Protein 1 antibodyAnti-CREB1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
