Anti-Phospho-c Myb-Ser11 antibody [R04-2D3] (STJA0034999)

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STJA0034999
£133.50 - £281.50
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Host: Rabbit
Applications: WB/IHC-P/IP/ChIP
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal anti-Phospho-c Myb-Ser11 for use in WB, IHC-P, IP and ChIP in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : R04-2D3
Conjugation: Unconjugated
Isotype: IgG
Formulation: 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Purification: Affinity Purified
Concentration: 0.3 mg/mL
Dilution Range: WB 1:500-1:1000
IHC 1:50-1:100
IP 1:20
ChIP 1:20
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: MYB
Gene ID: 4602
Uniprot ID: MYB_HUMAN
Immunogen: A synthetic phosphopeptide corresponding to residues surrounding Ser11 of human v-Myb/c-Myb
Post Translational Modifications Ubiquitinated.mediated by SIAH1 and leading to its subsequent proteasomal degradation. SUMOylated by TRAF7.leading to MYB transcriptional activity inhibition. Phosphorylated by NLK on multiple sites, which induces proteasomal degradation. Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels.
Function Transcriptional activator.DNA-binding protein that specifically recognize the sequence 5'-YAACGTG-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Protein Name Transcriptional Activator Myb
Proto-Oncogene C-Myb
Database Links Reactome: R-HSA-8939236
Reactome: R-HSA-9018519
Reactome: R-HSA-9616222
Reactome: R-HSA-983231
Reactome: R-HSA-9834899
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Transcriptional Activator Myb antibody
Anti-Proto-Oncogene C-Myb antibody
Anti-MYB antibody

Information sourced from Uniprot.org

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