| Function | Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport. |
| Protein Name | Bag Family Molecular Chaperone Regulator 3Bag-3Bcl-2-Associated Athanogene 3Bcl-2-Binding Protein BisDocking Protein Cair-1 |
| Database Links | Reactome: R-HSA-3371453 |
| Cellular Localisation | NucleusCytoplasmColocalizes With Hsf1 To The Nucleus Upon Heat Stress |
| Alternative Antibody Names | Anti-Bag Family Molecular Chaperone Regulator 3 antibodyAnti-Bag-3 antibodyAnti-Bcl-2-Associated Athanogene 3 antibodyAnti-Bcl-2-Binding Protein Bis antibodyAnti-Docking Protein Cair-1 antibodyAnti-BAG3 antibodyAnti-BIS antibody |
Information sourced from Uniprot.org
