• Western Blot analysis of K-562 mouse heart, rat heart using primary antibody at 1:1000 dilution 4°C, overnight. Secondary antibody (STJS000791) was diluted at 1:10000 25°C, 1. 5hours

Anti-Phospho-BAG3-Tyr457 antibody (STJA0009957)

SKU:
STJA0009957

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-BAG family molecular chaperone regulator 3-Tyr457 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BAG3
Gene ID: 9531
Uniprot ID: BAG3_HUMAN
Specificity: This antibody detects endogenous levels of BAG3 (Phospho-Tyr457) at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human BAG3 (Phospho-Tyr457)
Function Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70. Has anti-apoptotic activity. Plays a role in the HSF1 nucleocytoplasmic transport.
Protein Name Bag Family Molecular Chaperone Regulator 3
Bag-3
Bcl-2-Associated Athanogene 3
Bcl-2-Binding Protein Bis
Docking Protein Cair-1
Database Links Reactome: R-HSA-3371453
Cellular Localisation Nucleus
Cytoplasm
Colocalizes With Hsf1 To The Nucleus Upon Heat Stress
Alternative Antibody Names Anti-Bag Family Molecular Chaperone Regulator 3 antibody
Anti-Bag-3 antibody
Anti-Bcl-2-Associated Athanogene 3 antibody
Anti-Bcl-2-Binding Protein Bis antibody
Anti-Docking Protein Cair-1 antibody
Anti-BAG3 antibody
Anti-BIS antibody

Information sourced from Uniprot.org

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