| Short Description : | Rabbit polyclonal anti-Phospho-Sodium/potassium-transporting ATPase subunit alpha-1/K+ ATPase alpha-1 subunit-Tyr260 (230-290 aa) for use in WB, ELISA and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and rela |
| Applications: | WB/ELISA/IHC |
| Host: | Rabbit |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ATP1A1 |
| Gene ID: | 476 |
| Uniprot ID: | AT1A1_HUMAN |
| Immunogen: | Synthetic peptide from the human protein at the amino acid range 230-290 |
| Immunogen Region: | 230-290 aa |
| Specificity: | The antibody detects endogenous Sodium Potassium ATPase alpha-1 when Phospho occurs at Tyr260) |
| Function | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis. |
| Protein Name | Sodium/Potassium-Transporting Atpase Subunit Alpha-1Na(+/K(+ Atpase Alpha-1 SubunitSodium Pump Subunit Alpha-1 |
| Database Links | Reactome: R-HSA-5578775Reactome: R-HSA-936837Reactome: R-HSA-9679191 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneSarcolemmaCell ProjectionAxonMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Sodium/Potassium-Transporting Atpase Subunit Alpha-1 antibodyAnti-Na(+/K(+ Atpase Alpha-1 Subunit antibodyAnti-Sodium Pump Subunit Alpha-1 antibodyAnti-ATP1A1 antibody |
Information sourced from Uniprot.org
