Host: | Rabbit |
Applications: | IHC/IF/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Phospho-Amyloid beta precursor like protein 2 precursor-like protein 2-Tyr755 (714-763 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | APLP2 |
Gene ID: | 334 |
Uniprot ID: | APLP2_HUMAN |
Immunogen Region: | 714-763 aa |
Specificity: | Phospho-APLP2 (Y755) Polyclonal Antibody detects endogenous levels of APLP2 protein only when phosphorylated at Y755. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human APLP2 around the phosphorylation site of Tyr755 at the amino acid range 714-763 |
Post Translational Modifications | The BPTI/Kunitz inhibitor domain is O-glycosylated. |
Function | May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts. |
Protein Name | Amyloid Beta Precursor Like Protein 2ApphAmyloid BetaA4 Precursor-Like Protein 2Amyloid Protein HomologAmyloid-Like Protein 2Aplp-2Cdei Box-Binding ProteinCdebpSperm Membrane Protein Ywk-Ii |
Database Links | Reactome: R-HSA-114608Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinNucleus |
Alternative Antibody Names | Anti-Amyloid Beta Precursor Like Protein 2 antibodyAnti-Apph antibodyAnti-Amyloid Beta antibodyAnti-A4 Precursor-Like Protein 2 antibodyAnti-Amyloid Protein Homolog antibodyAnti-Amyloid-Like Protein 2 antibodyAnti-Aplp-2 antibodyAnti-Cdei Box-Binding Protein antibodyAnti-Cdebp antibodyAnti-Sperm Membrane Protein Ywk-Ii antibodyAnti-APLP2 antibodyAnti-APPL2 antibody |
Information sourced from Uniprot.org