| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PHKB |
| Gene ID: | 5257 |
| Uniprot ID: | KPBB_HUMAN |
| Immunogen Region: | 854-1093 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 854-1093 of human PHKB (NP_000284.1). |
| Immunogen Sequence: | VIHIGWIISNNPELFSGMLK IRIGWIIHAMEYELQIRGGD KPALDLYQLSPSEVKQLLLD ILQPQQNGRCWLNRRQIDGS LNRTPTGFYDRVWQILERTP NGIIVAGKHLPQQPTLSDMT MYEMNFSLLVEDTLGNIDQP QYRQIVVELLMVVSIVLERN PELEFQDKVDLDRLVKEAFN EFQKDQSRLKEIEKQDDMTS FYNTPPLGKRGTCSYLTKAV MNLLLEGEVKPNNDDPCLI |
| Post Translational Modifications | Ser-701 is probably phosphorylated by PKA. Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated. |
| Function | Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation. |
| Protein Name | Phosphorylase B Kinase Regulatory Subunit BetaPhosphorylase Kinase Subunit Beta |
| Database Links | Reactome: R-HSA-70221 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic Side |
| Alternative Antibody Names | Anti-Phosphorylase B Kinase Regulatory Subunit Beta antibodyAnti-Phosphorylase Kinase Subunit Beta antibodyAnti-PHKB antibody |
Information sourced from Uniprot.org