| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PHF13 |
| Gene ID: | 148479 |
| Uniprot ID: | PHF13_HUMAN |
| Immunogen Region: | 1-300 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PHF13 (NP_722519.2). |
| Immunogen Sequence: | MDSDSCAAAFHPEEYSPSCK RRRTVEDFNKFCTFVLAYAG YIPYPKEELPLRSSPSPANS TAGTIDSDGWDAGFSDIASS VPLPVSDRCFSHLQPTLLQR AKPSNFLLDRKKTDKLKKKK KRKRRDSDAPGKEGYRGGLL KLEAADPYVETPTSPTLQDI PQAPSDPCSGWDSDTPSSGS CATVSPDQVKEIKTEGKRTI VRQGKQVVFRDEDSTGNDED IMVDSDDDSWDLVTCFCMK |
| Post Translational Modifications | Subject to proteasomal degradation. Stable when bound to chromatin. The soluble form is rapidly degraded. |
| Function | Modulates chromatin structure and DNA damage response by regulating key determinants of chromatin compaction and DNA damage response. Binds H3K4me3-containing chromatin and promotes DNA condensation by recruiting corepressors such as TRIM28 and H3K9 methyltransferase SETDB1. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis. Increases both chromatin-associated levels and activity of H3K9 methyltransferases, such as SETDB1, thus enhancing H3K9 trimethylation. Essential for testicular stem-cell differentiation and sustained spermatogenesis. |
| Protein Name | Phd Finger Protein 13 Survival Time-Associated Phd Finger Protein In Ovarian Cancer 1 Spoc1 |
| Cellular Localisation | Nucleus Nucleoplasm Predominantly Bound To Chromatin But A Minor Proportion Is Also Detected In The Nucleoplasm |
| Alternative Antibody Names | Anti-Phd Finger Protein 13 antibody Anti-Survival Time-Associated Phd Finger Protein In Ovarian Cancer 1 antibody Anti-Spoc1 antibody Anti-PHF13 antibody |
Information sourced from Uniprot.org