| Post Translational Modifications | Subject to proteasomal degradation. Stable when bound to chromatin. The soluble form is rapidly degraded. |
| Function | Modulates chromatin structure and DNA damage response by regulating key determinants of chromatin compaction and DNA damage response. Binds H3K4me3-containing chromatin and promotes DNA condensation by recruiting corepressors such as TRIM28 and H3K9 methyltransferase SETDB1. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis. Increases both chromatin-associated levels and activity of H3K9 methyltransferases, such as SETDB1, thus enhancing H3K9 trimethylation. Essential for testicular stem-cell differentiation and sustained spermatogenesis. |
| Protein Name | Phd Finger Protein 13Survival Time-Associated Phd Finger Protein In Ovarian Cancer 1Spoc1 |
| Cellular Localisation | NucleusNucleoplasmPredominantly Bound To ChromatinBut A Minor Proportion Is Also Detected In The Nucleoplasm |
| Alternative Antibody Names | Anti-Phd Finger Protein 13 antibodyAnti-Survival Time-Associated Phd Finger Protein In Ovarian Cancer 1 antibodyAnti-Spoc1 antibodyAnti-PHF13 antibody |
Information sourced from Uniprot.org
