| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-PGRMC1/MPR (C-Term) is suitable for use in ELISA, Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:4000.WB: Approx 24kDa band observed in Human Kidney, Liver and Testis lysates, and approx 25kDa in Mouse Testis lysates (calculated MW of 21.7kDa according to Human NP_006658.1 and Mouse NP_0580 |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
PGRMC1 |
| Gene ID: |
10857 |
| Uniprot ID: |
PGRC1_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_006658.1 |
| Immunogen Sequence: |
EPKDESARKND |
| Post Translational Modifications | O-glycosylated.contains chondroitin sulfate attached to Ser-54. Ser-54 is in the cytoplasmic domain but the glycosylated form was detected in urine, suggesting that the membrane-bound form is cleaved, allowing for production of a secreted form which is glycosylated. |
| Function | Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins. Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization. |
| Protein Name | Membrane-Associated Progesterone Receptor Component 1MprDap1Iza |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Microsome MembraneSingle-Pass Membrane ProteinSmooth Endoplasmic Reticulum MembraneMitochondrion Outer MembraneExtracellular SideSecretedLocalized At Cell MembraneProbably In Lipid RaftsIn Serum-Starved Conditions |
| Alternative Antibody Names | Anti-Membrane-Associated Progesterone Receptor Component 1 antibodyAnti-Mpr antibodyAnti-Dap1 antibodyAnti-Iza antibodyAnti-PGRMC1 antibodyAnti-HPR6.6 antibodyAnti-PGRMC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
