| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PFN2 |
| Gene ID: | 5217 |
| Uniprot ID: | PROF2_HUMAN |
| Immunogen Region: | 1-140 |
| Immunogen Sequence: | MAGWQSYVDNLMCDGCCQEA AIVGYCDAKYVWAATAGGVF QSITPIEIDMIVGKDREGFF TNGLTLGAKKCSVIRDSLYV DGDCTMDIRTKSQGGEPTYN VAVGRAGRVLVFVMGKEGVH GGGLNKKAYSMAKYLRDSGF |
| Specificity: | Recombinant Protein corresponding to a sequence within amino acids 1-140 of human PFN2 (NP_444252.1). |
| Tissue Specificity | Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver. |
| Function | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. |
| Protein Name | Profilin-2Profilin Ii |
| Database Links | Reactome: R-HSA-376176Reactome: R-HSA-5663220 |
| Cellular Localisation | CytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Profilin-2 antibodyAnti-Profilin Ii antibodyAnti-PFN2 antibody |
Information sourced from Uniprot.org
