| Tissue Specificity | Expressed in the retina, at higher levels in the photoreceptor layer at the joint between the outer and inner segments. |
| Function | Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5. |
| Protein Name | Peroxisomal Atpase Pex6Peroxin-6Peroxisomal Biogenesis Factor 6Peroxisomal-Type Atpase 1Peroxisome Assembly Factor 2Paf-2 |
| Database Links | Reactome: R-HSA-9033241 |
| Cellular Localisation | CytoplasmCytosolPeroxisome MembraneCell ProjectionCiliumPhotoreceptor Outer SegmentAssociated With Peroxisomal MembranesAnchored By Pex26 To Peroxisome MembranesLocalized At The Base Of The Outer Segment Of Photoreceptor Cells |
| Alternative Antibody Names | Anti-Peroxisomal Atpase Pex6 antibodyAnti-Peroxin-6 antibodyAnti-Peroxisomal Biogenesis Factor 6 antibodyAnti-Peroxisomal-Type Atpase 1 antibodyAnti-Peroxisome Assembly Factor 2 antibodyAnti-Paf-2 antibodyAnti-PEX6 antibodyAnti-PXAAA1 antibody |
Information sourced from Uniprot.org
