| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PEX6 (741-980) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PEX6 |
| Gene ID: |
5190 |
| Uniprot ID: |
PEX6_HUMAN |
| Immunogen Region: |
741-980 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 741-980 of human PEX6 (NP_000278.3). |
| Immunogen Sequence: |
LLHGPPGTGKTLLAKAVATE CSLTFLSVKGPELINMYVGQ SEENVREVFARARAAAPCII FFDELDSLAPSRGRSGDSGG VMDRVVSQLLAELDGLHSTQ DVFVIGATNRPDLLDPALLR PGRFDKLVFVGANEDRASQL RVLSAITRKFKLEPSVSLVN VLDCCPPQLTGADLYSLCSD AMTAALKRRVHDLEEGLEPG SSALMLTMEDLLQAAARLQP SVSEQELLRYKRIQRKFAA |
| Tissue Specificity | Expressed in the retina, at higher levels in the photoreceptor layer at the joint between the outer and inner segments. |
| Function | Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5. |
| Protein Name | Peroxisomal Atpase Pex6Peroxin-6Peroxisomal Biogenesis Factor 6Peroxisomal-Type Atpase 1Peroxisome Assembly Factor 2Paf-2 |
| Database Links | Reactome: R-HSA-9033241 |
| Cellular Localisation | CytoplasmCytosolPeroxisome MembraneCell ProjectionCiliumPhotoreceptor Outer SegmentAssociated With Peroxisomal MembranesAnchored By Pex26 To Peroxisome MembranesLocalized At The Base Of The Outer Segment Of Photoreceptor Cells |
| Alternative Antibody Names | Anti-Peroxisomal Atpase Pex6 antibodyAnti-Peroxin-6 antibodyAnti-Peroxisomal Biogenesis Factor 6 antibodyAnti-Peroxisomal-Type Atpase 1 antibodyAnti-Peroxisome Assembly Factor 2 antibodyAnti-Paf-2 antibodyAnti-PEX6 antibodyAnti-PXAAA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
