• Western blot with Anti-PELO Antibody (STJ502411) on 1) Mouse liver, 2) PELO peptide. Antibody at 1:500 dilution in buffer. From 10% SDS gel.

Anti-PELO antibody (330-380) (STJ502411)

SKU:
STJ502411-100

£441.50
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Host: Rabbit
Applications: DB/ELISA/IHC/IP/WB
Reactivity: Human/Monkey/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PELO (330-380) is suitable for use in Dot Blot, ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.68-0.70 µg/µl
Dilution Range: WB: 1:500
DB: 1:4, 000
ELISA: 1:4, 000
IP: 1:150
IHC: 1:50-1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PELO
Gene ID: 53918
Uniprot ID: PELO_HUMAN
Immunogen Region: 330-380
Immunogen: Synthetic peptide taken within amino acid region 330-380 on human PELOTA protein.
Tissue Specificity Ubiquitously expressed.
Function Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy.
Protein Name Protein Pelota Homolog
Hpelota
Protein Dom34 Homolog
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Protein Pelota Homolog antibody
Anti-Hpelota antibody
Anti-Protein Dom34 Homolog antibody
Anti-PELO antibody
Anti-CGI-17 antibody

Information sourced from Uniprot.org

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