| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PELI3 (1-280) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PELI3 |
| Gene ID: |
246330 |
| Uniprot ID: |
PELI3_HUMAN |
| Immunogen Region: |
1-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human PELI3 (NP_659502.2). |
| Immunogen Sequence: |
MVLEGNPEVGSPRTSDLQHR GNKGSCVLSSPGEDAQPGEE PIKYGELIVLGCCEEGGEET EAQRGEVTGPRAHSCYNGCL ASGDKGRRRSRLALSRRSHA NGVKPDVMHHISTPLVSKAL SNRGQHSISYTLSRSHSVIV EYTHDSDTDMFQIGRSTENM IDFVVTDTSPGGGAAEGPSA QSTISRYACRILCDRRPPYT ARIYAAGFDASSNIFLGERA AKWRTPDGLMDGLTTNGVL |
| Tissue Specificity | Highly expressed in brain, heart and testis, and at lower level in kidney, liver, lung, placenta, small intestine, spleen and stomach. Isoform 1 is not expressed in lung. |
| Post Translational Modifications | Phosphorylated by IRAK1 enhancing its E3 ligase activity. |
| Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Acts as a regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling. Catalyzes 'Lys-63'-linked polyubiquitination of RIPK2 in parallel of XIAP. |
| Protein Name | E3 Ubiquitin-Protein Ligase Pellino Homolog 3Pellino-3 |
| Database Links | Reactome: R-HSA-9020702Reactome: R-HSA-937039Reactome: R-HSA-975144 |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Pellino Homolog 3 antibodyAnti-Pellino-3 antibodyAnti-PELI3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
