| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:10-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PDLIM1 |
| Gene ID: | 9124 |
| Uniprot ID: | PDLI1_HUMAN |
| Immunogen Region: | 1-329 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-329 of human PDLIM1/CLP36 (NP_066272.1). |
| Immunogen Sequence: | MTTQQIDLQGPGPWGFRLVG GKDFEQPLAISRVTPGSKAA LANLCIGDVITAIDGENTSN MTHLEAQNRIKGCTDNLTLT VARSEHKVWSPLVTEEGKRH PYKMNLASEPQEVLHIGSAH NRSAMPFTASPASSTTARVI TNQYNNPAGLYSSENISNFN NALESKTAASGVEANSRPLD HAQPPSSLVIDKESEVYKML QEKQELNEPPKQSTSFLVLQ EILESEEKGDPNKPSGFRS |
| Tissue Specificity | Strongly expressed in the heart and skeletal muscle, moderately expressed in the spleen, small intestine, colon, placenta, and lung. A lower level expression is seen in liver, thymus, kidney, prostate and pancreas and is not found in the brain, testis, ovary, and peripheral blood leukocytes. |
| Function | Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton. Involved in assembly, disassembly and directioning of stress fibers in fibroblasts. Required for the localization of ACTN1 and PALLD to stress fibers. Required for cell migration and in maintaining cell polarity of fibroblasts. |
| Protein Name | Pdz And Lim Domain Protein 1C-Terminal Lim Domain Protein 1ElfinLim Domain Protein Clp-36 |
| Cellular Localisation | CytoplasmCytoskeletonMyofibrilSarcomereZ LineAssociates With Actin Stress Fibers |
| Alternative Antibody Names | Anti-Pdz And Lim Domain Protein 1 antibodyAnti-C-Terminal Lim Domain Protein 1 antibodyAnti-Elfin antibodyAnti-Lim Domain Protein Clp-36 antibodyAnti-PDLIM1 antibodyAnti-CLIM1 antibodyAnti-CLP36 antibody |
Information sourced from Uniprot.org