| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PDK3 |
| Gene ID: | 5165 |
| Uniprot ID: | PDK3_HUMAN |
| Immunogen Region: | 137-406 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 137-406 of human PDK3 (NP_005382.1). |
| Immunogen Sequence: | FGFDPFISTNIQYFLDRFYT NRISFRMLINQHTLLFGGDT NPVHPKHIGSIDPTCNVADV VKDAYETAKMLCEQYYLVAP ELEVEEFNAKAPDKPIQVVY VPSHLFHMLFELFKNSMRAT VELYEDRKEGYPAVKTLVTL GKEDLSIKISDLGGGVPLRK IDRLFNYMYSTAPRPSLEPT RAAPLAGFGYGLPISRLYAR YFQGDLKLYSMEGVGTDAVI YLKALSSESFERLPVFNKS |
| Tissue Specificity | Expressed in heart, skeletal muscle, spinal cord, as well as fetal and adult brain. |
| Function | Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. |
| Protein Name | Pyruvate Dehydrogenase Acetyl-Transferring Kinase Isozyme 3 - Mitochondrial Pyruvate Dehydrogenase Kinase Isoform 3 |
| Database Links | Reactome: R-HSA-204174 Reactome: R-HSA-5362517 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Pyruvate Dehydrogenase antibody Anti-Acetyl-Transferring Kinase Isozyme 3 - Mitochondrial antibody Anti-Pyruvate Dehydrogenase Kinase Isoform 3 antibody Anti-PDK3 antibody Anti-PDHK3 antibody |
Information sourced from Uniprot.org