| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-cAMP-specific 3 NA, 5 cyclic phosphodiesterase 4A (530-580) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PDE4A |
| Gene ID: |
5141 |
| Uniprot ID: |
PDE4A_HUMAN |
| Immunogen Region: |
530-580 |
| Specificity: |
This antibody detects endogenous levels of PDE4A at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human PDE4A AA range:530-580 |
| Post Translational Modifications | Isoform 1: Proteolytically cleaved by CASP3. Isoform 2: Phosphorylated at Ser-119 by PKA. |
| Function | Hydrolyzes the second messenger 3',5'-cyclic AMP (cAMP), which is a key regulator of many important physiological processes. Isoform 1: Efficiently hydrolyzes cAMP. Isoform 2: Efficiently hydrolyzes cAMP. Isoform 3: Efficiently hydrolyzes cAMP. The phosphodiesterase activity is not affected by calcium, calmodulin or cyclic GMP (cGMP) levels. Does not hydrolyze cGMP. Isoform 4: Efficiently hydrolyzes cAMP. Isoform 6: Efficiently hydrolyzes cAMP. Isoform 7: Efficiently hydrolyzes cAMP. |
| Protein Name | Camp-Specific 3' -5'-Cyclic Phosphodiesterase 4aDpde2Pde46 |
| Database Links | Reactome: R-HSA-180024Reactome: R-HSA-418555 |
| Cellular Localisation | Isoform 1: CytoplasmPerinuclear RegionIsoform 2: CytoplasmCell ProjectionRuffle MembraneIsoform 3: CytoplasmCytosolIsoform 4: MembranePeripheral Membrane ProteinIsoform 4 Has Propensity For Association With MembranesIsoform 6: CytoplasmIsoform 7: CytoplasmMembranePredominantly Cytosolic |
| Alternative Antibody Names | Anti-Camp-Specific 3' -5'-Cyclic Phosphodiesterase 4a antibodyAnti-Dpde2 antibodyAnti-Pde46 antibodyAnti-PDE4A antibodyAnti-DPDE2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
