| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PDE3B |
| Gene ID: | 5140 |
| Uniprot ID: | PDE3B_HUMAN |
| Immunogen Region: | 400-660 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 400-660 of human PDE3B (NP_000913.2). |
| Immunogen Sequence: | PLTPFPGFYPCSEIEDPAEK GDRKLNKGLNRNSLPTPQLR RSSGTSGLLPVEQSSRWDRN NGKRPHQEFGISSQGCYLNG PFNSNLLTIPKQRSSSVSLT HHVGLRRAGVLSSLSPVNSS NHGPVSTGSLTNRSPIEFPD TADFLNKPSVILQRSLGNAP NTPDFYQQLRNSDSNLCNSC GHQMLKYVSTSESDGTDCCS GKSGEEENIFSKESFKLMET QQEEETEKKDSRKLFQEGD |
| Tissue Specificity | Abundant in adipose tissues. |
| Post Translational Modifications | Phosphorylation at Ser-295 mediates insulin-induced activation of PDE3B. |
| Function | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process. Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling. Controls cardiac contractility by reducing cAMP concentration in cardiocytes. |
| Protein Name | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3bCgipde1Cgip1Cyclic Gmp-Inhibited Phosphodiesterase BCgi-Pde B |
| Database Links | Reactome: R-HSA-165160Reactome: R-HSA-418555 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b antibodyAnti-Cgipde1 antibodyAnti-Cgip1 antibodyAnti-Cyclic Gmp-Inhibited Phosphodiesterase B antibodyAnti-Cgi-Pde B antibodyAnti-PDE3B antibody |
Information sourced from Uniprot.org