| Function | Cyclic nucleotide phosphodiesterase with specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has also activity toward cUMP. Independently of its catalytic activity it is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling. |
| Protein Name | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3aCyclic Gmp-Inhibited Phosphodiesterase ACgi-Pde ACgmp-Inhibited Camp PhosphodiesteraseCgi-Pde |
| Database Links | Reactome: R-HSA-418555 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmCytosol |
| Alternative Antibody Names | Anti-Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3a antibodyAnti-Cyclic Gmp-Inhibited Phosphodiesterase A antibodyAnti-Cgi-Pde A antibodyAnti-Cgmp-Inhibited Camp Phosphodiesterase antibodyAnti-Cgi-Pde antibodyAnti-PDE3A antibody |
Information sourced from Uniprot.org
