| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PDCD10 |
| Gene ID: | 11235 |
| Uniprot ID: | PDC10_HUMAN |
| Immunogen Region: | 1-212 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-212 of human PDCD10 (NP_009148.2). |
| Immunogen Sequence: | MRMTMEEMKNEAETTSMVSM PLYAVMYPVFNELERVNLSA AQTLRAAFIKAEKENPGLTQ DIIMKILEKKSVEVNFTESL LRMAADDVEEYMIERPEPEF QDLNEKARALKQILSKIPDE INDRVRFLQTIKDIASAIKE LLDTVNNVFKKYQYQNRRAL EHQKKEFVKYSKSFSDTLKT YFKDGKAINVFVSANRLIHQ TNLILQTFKTVA |
| Tissue Specificity | Ubiquitous. |
| Function | Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development. |
| Protein Name | Programmed Cell Death Protein 10 Cerebral Cavernous Malformations 3 Protein Tf-1 Cell Apoptosis-Related Protein 15 |
| Cellular Localisation | Cytoplasm Golgi Apparatus Membrane Peripheral Membrane Protein Cytoplasmic Side Cell Membrane |
| Alternative Antibody Names | Anti-Programmed Cell Death Protein 10 antibody Anti-Cerebral Cavernous Malformations 3 Protein antibody Anti-Tf-1 Cell Apoptosis-Related Protein 15 antibody Anti-PDCD10 antibody Anti-CCM3 antibody Anti-TFAR15 antibody |
Information sourced from Uniprot.org