| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PCSK4 (440-710) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PCSK4 |
| Gene ID: |
54760 |
| Uniprot ID: |
PCSK4_HUMAN |
| Immunogen Region: |
440-710 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 440-710 of human PCSK4 (NP_060043.2). |
| Immunogen Sequence: |
VDTARTWLPTQPQRKCAVRV QSRPTPILPLIYIRENVSAC AGLHNSIRSLEHVQAQLTLS YSRRGDLEISLTSPMGTRST LVAIRPLDVSTEGYNNWVFM STHFWDENPQGVWTLGLENK GYYFNTGTLYRYTLLLYGTA EDMTARPTGPQVTSSACVQR DTEGLCQACDGPAYILGQLC LAYCPPRFFNHTRLVTAGPG HTAAPALRVCSSCHASCYTC RGGSPRDCTSCPPSSTLDQ |
| Tissue Specificity | Placenta. |
| Post Translational Modifications | N-glycosylated. Synthesized in the endoplasmic reticulum as a zymogen, is matured by autocatalytic cleavage between the prodomain and the catalytic domain. |
| Function | Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida. Also plays a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2. May also participate in folliculogenesis in the ovaries. |
| Protein Name | Proprotein Convertase Subtilisin/Kexin Type 4Proprotein Convertase 4Pc4 |
| Cellular Localisation | MembraneSingle-Pass Membrane ProteinCytoplasmic VesicleSecretory VesicleAcrosome Membrane |
| Alternative Antibody Names | Anti-Proprotein Convertase Subtilisin/Kexin Type 4 antibodyAnti-Proprotein Convertase 4 antibodyAnti-Pc4 antibodyAnti-PCSK4 antibodyAnti-PC4 antibodyAnti-UNQ2757 antibodyAnti-PRO6496 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
