| Tissue Specificity | Expressed in all tissues tested, including placenta, liver, kidney and thymus. |
| Post Translational Modifications | Cleaved during mitotis which leads to removal of CDK5RAP2 from the centrosome and promotes centriole disengagement and subsequent centriole separation. The C-terminal fragment is rapidly degraded following cleavage. Ubiquitinated by TRIM43.leading to proteasomal degradation. |
| Function | Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome. |
| Protein Name | PericentrinKendrinPericentrin-B |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518Reactome: R-HSA-9613829Reactome: R-HSA-9615710Reactome: R-HSA-9646399 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrosomal At All Stages Of The Cell CycleRemains Associated With Centrosomes Following Microtubule DepolymerizationColocalized With Disc1 At The Centrosome |
| Alternative Antibody Names | Anti-Pericentrin antibodyAnti-Kendrin antibodyAnti-Pericentrin-B antibodyAnti-PCNT antibodyAnti-KIAA0402 antibodyAnti-PCNT2 antibody |
Information sourced from Uniprot.org
