| Host: | Rabbit |
| Applications: | WB/IF/ICC/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PCMT1 |
| Gene ID: | 5110 |
| Uniprot ID: | PIMT_HUMAN |
| Immunogen Region: | 62-286 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 62-286 of human PCMT1 (NP_001238978.1). |
| Immunogen Sequence: | KSGGASHSELIHNLRKNGII KTDKVFEVMLATDRSHYAKC NPYMDSPQSIGFQATISAPH MHAYALELLFDQLHEGAKAL DVGSGSGILTACFARMVGCT GKVIGIDHIKELVDDSVNNV RKDDPTLLSSGRVQLVVGDG RMGYAEEAPYDAIHVGAAAP VVPQALIDQLKPGGRLILPV GPAGGNQMLEQYDKLQDGSI KMKPLMGVIYVPLTDKEKQW SRDEL |
| Function | Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein. |
| Protein Name | Protein-L-Isoaspartate(D-Aspartate O-MethyltransferasePimtL-Isoaspartyl Protein Carboxyl MethyltransferaseProtein L-Isoaspartyl/D-Aspartyl MethyltransferaseProtein-Beta-Aspartate Methyltransferase |
| Database Links | Reactome: R-HSA-5676934 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Protein-L-Isoaspartate(D-Aspartate O-Methyltransferase antibodyAnti-Pimt antibodyAnti-L-Isoaspartyl Protein Carboxyl Methyltransferase antibodyAnti-Protein L-Isoaspartyl/D-Aspartyl Methyltransferase antibodyAnti-Protein-Beta-Aspartate Methyltransferase antibodyAnti-PCMT1 antibody |
Information sourced from Uniprot.org