| Host: | Rabbit |
| Applications: | WB/IHC-P/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:100IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PCIF1 |
| Gene ID: | 63935 |
| Uniprot ID: | CAPAM_HUMAN |
| Immunogen Region: | 1-200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human PCIF1 (NP_071387.1). |
| Immunogen Sequence: | MANENHGSPREEASLLSHSP GTSNQSQPCSPKPIRLVQDL PEELVHAGWEKCWSRRENRP YYFNRFTNQSLWEMPVLGQH DVISDPLGLNATPLPQDSSL VETPPAENKPRKRQLSEEQP SGNGVKKPKIEIPVTPTGQS VPSSPSIPGTPTLKMWGTSP EDKQQAALLRPTEVYWDLDI QTNAVIKHRGPSEVLPPHPE |
| Tissue Specificity | Ubiquitous. |
| Function | Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs. Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally. |
| Protein Name | Mrna2'-O-Methyladenosine-N(6--MethyltransferaseCap-Specific Adenosine MethyltransferaseCapamHcapamPhosphorylated Ctd-Interacting Factor 1Hpcif1Protein Phosphatase 1 Regulatory Subunit 121 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Mrna antibodyAnti-2'-O-Methyladenosine-N(6--Methyltransferase antibodyAnti-Cap-Specific Adenosine Methyltransferase antibodyAnti-Capam antibodyAnti-Hcapam antibodyAnti-Phosphorylated Ctd-Interacting Factor 1 antibodyAnti-Hpcif1 antibodyAnti-Protein Phosphatase 1 Regulatory Subunit 121 antibodyAnti-PCIF1 antibodyAnti-C20orf67 antibodyAnti-CAPAM antibodyAnti-PPP1R121 antibody |
Information sourced from Uniprot.org