Anti-PCGF6 antibody (STJA0007118)

SKU:
STJA0007118
£48.00 - £252.00
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Polycomb group RING finger protein 6 is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PCGF6
Gene ID: 84108
Uniprot ID: PCGF6_HUMAN
Specificity: This antibody detects endogenous levels of PCGF6 at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human PCGF6
Post Translational Modifications Phosphorylated during mitosis. Phosphorylated on Ser-30 by CDK7 in vitro.
Function Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.
Protein Name Polycomb Group Ring Finger Protein 6
Mel18 And Bmi1-Like Ring Finger
Ring Finger Protein 134
Database Links Reactome: R-HSA-8953750
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Polycomb Group Ring Finger Protein 6 antibody
Anti-Mel18 And Bmi1-Like Ring Finger antibody
Anti-Ring Finger Protein 134 antibody
Anti-PCGF6 antibody
Anti-MBLR antibody
Anti-RNF134 antibody

Information sourced from Uniprot.org

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