| Short Description : | Rabbit polyclonal PCGF6 (161-350) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PCGF6 |
| Gene ID: | 84108 |
| Uniprot ID: | PCGF6_HUMAN |
| Immunogen Region: | 161-350 |
| Immunogen Sequence: | RHFYYSNRCPKCNIVVHQTQ PLYNIRLDRQLQDIVYKLVI NLEEREKKQMHDFYKERGLE VPKPAVPQPVPSSKGRSKKV LESVFRIPPELDMSLLLEFI GANEGTGHFKPLEKKFVRVS GEATIGHVEKFLRRKMGLDP ACQVDIICGDHLLEQYQTLR EIRRAIGDAAMQDGLLVLHY GLVVSPLKIT |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 161-350 of human PCGF6 (NP_001011663.1). |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylated during mitosis. Phosphorylated on Ser-30 by CDK7 in vitro. |
| Function | Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. |
| Protein Name | Polycomb Group Ring Finger Protein 6Mel18 And Bmi1-Like Ring FingerRing Finger Protein 134 |
| Database Links | Reactome: R-HSA-8953750 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Polycomb Group Ring Finger Protein 6 antibodyAnti-Mel18 And Bmi1-Like Ring Finger antibodyAnti-Ring Finger Protein 134 antibodyAnti-PCGF6 antibodyAnti-MBLR antibodyAnti-RNF134 antibody |
Information sourced from Uniprot.org
