Host: | Rabbit |
Applications: | WB/IHC-P/ELISA |
Reactivity: | Human/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | PBK |
Gene ID: | 55872 |
Uniprot ID: | TOPK_HUMAN |
Immunogen Region: | 1-322 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-322 of human SPK (NP_060962.2). |
Immunogen Sequence: | MEGISNFKTPSKLSEKKKSV LCSTPTINIPASPFMQKLGF GTGVNVYLMKRSPRGLSHSP WAVKKINPICNDHYRSVYQK RLMDEAKILKSLHHPNIVGY RAFTEANDGSLCLAMEYGGE KSLNDLIEERYKASQDPFPA AIILKVALNMARGLKYLHQE KKLLHGDIKSSNVVIKGDFE TIKICDVGVSLPLDENMTVT DPEACYIGTEPWKPKEAVEE NGVITDKADIFAFGLTLWE |
Tissue Specificity | Expressed in the testis and placenta. In the testis, restrictedly expressed in outer cell layer of seminiferous tubules. |
Post Translational Modifications | Phosphorylated.in a cell-cycle dependent manner at mitosis. |
Function | Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. |
Protein Name | Lymphokine-Activated Killer T-Cell-Originated Protein KinaseCancer/Testis Antigen 84Ct84Mapkk-Like Protein KinaseNori-3Pdz-Binding KinaseSpermatogenesis-Related Protein KinaseSpkT-Lak Cell-Originated Protein Kinase |
Alternative Antibody Names | Anti-Lymphokine-Activated Killer T-Cell-Originated Protein Kinase antibodyAnti-Cancer/Testis Antigen 84 antibodyAnti-Ct84 antibodyAnti-Mapkk-Like Protein Kinase antibodyAnti-Nori-3 antibodyAnti-Pdz-Binding Kinase antibodyAnti-Spermatogenesis-Related Protein Kinase antibodyAnti-Spk antibodyAnti-T-Lak Cell-Originated Protein Kinase antibodyAnti-PBK antibodyAnti-TOPK antibody |
Information sourced from Uniprot.org