• Immunofluorescence of mouse small intestine with Anti-Particulate Guanylate Cyclase C primary antibody (STJ502459). Red: Antibody immunoreactivity. Blue: Nuclei. Staining is found on the periphery of intestinal villi.

Anti-Particulate Guanylate Cyclase C antibody (C-Term) (STJ502459)

SKU:
STJ502459-100

£481.50
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Host: Rabbit
Applications: CM/ELISA/ICC/IF/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Particulate Guanylate Cyclase C (C-Term) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.75-1.20 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IHC: 1:200
ICC: 1:200
IF: 1:200
CFM: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Gucy2c
Gene ID: 25711
Uniprot ID: GUC2C_RAT
Immunogen Region: C-Term
Immunogen: Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase C protein.
Post Translational Modifications Glycosylation at Asn-74 and/or Asn-78 is required for interaction with VIP36 while glycosylation at Asn-401 modulates ligand-mediated GC-C activation.
Function Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. Receptor for the E.coli heat-stable enterotoxin.E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C.
Protein Name Guanylyl Cyclase C
Gc-C
Heat-Stable Enterotoxin Receptor
Sta Receptor
Intestinal Guanylate Cyclase
Database Links Reactome: R-RNO-8935690
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Endoplasmic Reticulum Membrane
The 145 Kda Plasma Membrane Form Of Gucy2c Contains Sialic Acid And Galactose Residues
While A Differencially Glycosylated 130 Kda Form Is A High Mannose Form That Is Resident In The Endoplasmic Reticulum And May Serve As The Precursor For The Cell Surface Form
Alternative Antibody Names Anti-Guanylyl Cyclase C antibody
Anti-Gc-C antibody
Anti-Heat-Stable Enterotoxin Receptor antibody
Anti-Sta Receptor antibody
Anti-Intestinal Guanylate Cyclase antibody
Anti-Gucy2c antibody
Anti-Guc2c antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance