| Post Translational Modifications | Auto-mono-ADP-ribosylated. Phosphorylated by PRKD1. |
| Function | Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Acts as an antiviral factor by cooperating with PARP11 to suppress Zika virus replication. Displays anti-alphavirus activity during IFN-gamma immune activation by directly ADP-ribosylating the alphaviral non-structural proteins nsP3 and nsP4. Acts as a component of the PRKD1-driven regulatory cascade that selectively controls a major branch of the basolateral transport pathway by catalyzing the MARylation of GOLGA1. Acts also as a key regulator of mitochondrial function, protein translation, and inflammation. Inhibits PINK1/Parkin-dependent mitophagy and promotes cartilage degeneration by inhibiting the ubiquitination and SUMOylation of MFN1/2 by upregulating ISG15 and ISGylation. |
| Protein Name | Protein Mono-Adp-Ribosyltransferase Parp12Adp-Ribosyltransferase Diphtheria Toxin-Like 12Artd12Poly Adp-Ribose Polymerase 12Parp-12Zinc Finger Ccch Domain-Containing Protein 1 |
| Database Links | |
| Cellular Localisation | NucleusGolgi ApparatusTrans-Golgi NetworkCytoplasmStress GranuleTranslocates From The Golgi Complex To Stress Granules Upon Stress Conditions |
| Alternative Antibody Names | Anti-Protein Mono-Adp-Ribosyltransferase Parp12 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 12 antibodyAnti-Artd12 antibodyAnti-Poly Adp-Ribose Polymerase 12 antibodyAnti-Parp-12 antibodyAnti-Zinc Finger Ccch Domain-Containing Protein 1 antibodyAnti-PARP12 antibodyAnti-ZC3HDC1 antibody |
Information sourced from Uniprot.org
