| Post Translational Modifications | Stimulated through its phosphorylation by CDK2. Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions. Phosphorylation is suppressed in growth-arrested cells. Auto-mono-ADP-ribosylated on glutamate and lysine residues. |
| Function | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity. Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA. |
| Protein Name | Protein Mono-Adp-Ribosyltransferase Parp10Adp-Ribosyltransferase Diphtheria Toxin-Like 10Artd10Poly Adp-Ribose Polymerase 10Parp-10 |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-9683610Reactome: R-HSA-9694631 |
| Cellular Localisation | NucleusNucleolusCytoplasmShuttles Between The Nuclear And Cytoplasmic CompartmentA Subpopulation Concentrates In The Nucleolus During Late G1/S Phase |
| Alternative Antibody Names | Anti-Protein Mono-Adp-Ribosyltransferase Parp10 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 10 antibodyAnti-Artd10 antibodyAnti-Poly Adp-Ribose Polymerase 10 antibodyAnti-Parp-10 antibodyAnti-PARP10 antibody |
Information sourced from Uniprot.org
