| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PARP10 (1-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PARP10 |
| Gene ID: |
84875 |
| Uniprot ID: |
PAR10_HUMAN |
| Immunogen Region: |
1-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PARP10 (NP_116178.2). |
| Immunogen Sequence: |
MVAMAEAEAGVAVEVRGLPP AVPDELLTLYFENRRRSGGG PVLSWQRLGCGGVLTFREPA DAERVLAQADHELHGAQLSL RPAPPRAPARLLLQGLPPGT TPQRLEQHVQALLRASGLPV QPCCALASPRPDRALVQLPK PLSEADVRVLEEQAQNLGLE GTLVSLARVPQARAVRVVGD GASVDLLLLELYLENERRSG GGPLEDLQRLPGPLGTVASF QQWQVAERVLQQEHRLQGS |
| Tissue Specificity | Highly expressed in spleen and thymus. Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes. Low expression in heart, brain, placenta, lung, skeletal muscle, and colon. |
| Post Translational Modifications | Stimulated through its phosphorylation by CDK2. Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions. Phosphorylation is suppressed in growth-arrested cells. Auto-mono-ADP-ribosylated on glutamate and lysine residues. |
| Function | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity. Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA. |
| Protein Name | Protein Mono-Adp-Ribosyltransferase Parp10Adp-Ribosyltransferase Diphtheria Toxin-Like 10Artd10Poly Adp-Ribose Polymerase 10Parp-10 |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-9683610Reactome: R-HSA-9694631 |
| Cellular Localisation | NucleusNucleolusCytoplasmShuttles Between The Nuclear And Cytoplasmic CompartmentA Subpopulation Concentrates In The Nucleolus During Late G1/S Phase |
| Alternative Antibody Names | Anti-Protein Mono-Adp-Ribosyltransferase Parp10 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 10 antibodyAnti-Artd10 antibodyAnti-Poly Adp-Ribose Polymerase 10 antibodyAnti-Parp-10 antibodyAnti-PARP10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
