| Function | Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation. |
| Protein Name | Terminal Nucleotidyltransferase 4aDna Polymerase SigmaLak-1Non-Canonical Poly(A Rna Polymerase Papd7Pap-Associated Domain-Containing Protein 7Tramp-Like Complex Polyadenylate PolymeraseTerminal GuanylyltransferaseTerminal Uridylyltransferase 5Tutase 5Topoisomerase-Related Function Protein 4-1Trf4-1 |
| Database Links | Reactome: R-HSA-6802952 |
| Cellular Localisation | CytoplasmNucleusNucleoplasmExcluded From NucleolusWeak Staining Detected In The Cytoplasm |
| Alternative Antibody Names | Anti-Terminal Nucleotidyltransferase 4a antibodyAnti-Dna Polymerase Sigma antibodyAnti-Lak-1 antibodyAnti-Non-Canonical Poly(A Rna Polymerase Papd7 antibodyAnti-Pap-Associated Domain-Containing Protein 7 antibodyAnti-Tramp-Like Complex Polyadenylate Polymerase antibodyAnti-Terminal Guanylyltransferase antibodyAnti-Terminal Uridylyltransferase 5 antibodyAnti-Tutase 5 antibodyAnti-Topoisomerase-Related Function Protein 4-1 antibodyAnti-Trf4-1 antibodyAnti-TENT4A antibodyAnti-PAPD7 antibodyAnti-POLS antibodyAnti-TRF4 antibody |
Information sourced from Uniprot.org
