| Host: | Rabbit |
| Applications: | IHC/IF |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Pan-Voltage-dependent L-type calcium channel subunit alpha-1C (1288-1338 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-200 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CACNA1C |
| Gene ID: | 775 |
| Uniprot ID: | CAC1C_HUMAN |
| Immunogen Region: | 1288-1338 aa |
| Specificity: | Cav pan Alpha 1 protein (A211) detects endogenous levels of Cav pan Alpha 1 |
| Immunogen: | Synthetic peptide derived from Cav pan Alpha 1 at the amino acid range 1288-1338 |
| Post Translational Modifications | Phosphorylation by PKA at Ser-1981 activates the channel. Elevated levels of blood glucose lead to increased phosphorylation by PKA. |
| Function | Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). Isoform 12: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 13: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 14: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 15: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 16: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 17: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 18: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 19: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 20: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 21: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 22: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 23: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 24: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 25: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 26: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 27: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Isoform 34: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. (Microbial infection) Acts as a receptor for Influenzavirus. May play a critical role in allowing virus entry when sialylated and expressed on lung tissues. |
| Protein Name | Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1c Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac Muscle Voltage-Gated Calcium Channel Subunit Alpha Cav1.2 |
| Database Links | Reactome: R-HSA-400042 Reactome: R-HSA-419037 Reactome: R-HSA-422356 Reactome: R-HSA-5576892 Reactome: R-HSA-5576893 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Sarcolemma Perikaryon Postsynaptic Density Membrane Cell Projection Dendrite T-Tubule Colocalizes With Ryanodine Receptors In Distinct Clusters At The Junctional Membrane Where The Sarcolemma And The Sarcoplasmic Reticulum Are In Close Contact The Interaction Between Rrad And Cacnb2 Promotes The Expression Of Cacna1c At The Cell Membrane |
| Alternative Antibody Names | Anti-Voltage-Dependent L-Type Calcium Channel Subunit Alpha-1c antibody Anti-Calcium Channel - L Type - Alpha-1 Polypeptide - Isoform 1 - Cardiac Muscle antibody Anti-Voltage-Gated Calcium Channel Subunit Alpha Cav1.2 antibody Anti-CACNA1C antibody Anti-CACH2 antibody Anti-CACN2 antibody Anti-CACNL1A1 antibody Anti-CCHL1A1 antibody |
Information sourced from Uniprot.org