Anti-PAIP1 antibody (1-260) (STJ27838)

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STJ27838
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PAIP1
Gene ID: 10605
Uniprot ID: PAIP1_HUMAN
Immunogen Region: 1-260
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PAIP1 (NP_877590.1).
Immunogen Sequence: MSDGFDRAPEQTRPLRAPPS SQDKIPQQNSESAMAKPQVV VAPVLMSKLSVNAPEFYPSG YSSSYTESYEDGCEDYPTLS EYVQDFLNHLTEQPGSFETE IEQFAETLNGCVTTDDALQE LVELIYQQATSIPNFSYMGA RLCNYLSHHLTISPQSGNFR QLLLQRCRTEYEVKDQAAKG DEVTRKRFHAFVLFLGELYL NLEIKGTNGQVTRADILQVG LRELLNALFSNPMDDNLIC
Function Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. (Microbial infection) Upon interaction with SARS coronavirus SARS-CoV NSP3 protein, plays an important role in viral protein synthesis.
Protein Name Polyadenylate-Binding Protein-Interacting Protein 1
Pabp-Interacting Protein 1
Paip-1
Poly(A-Binding Protein-Interacting Protein 1
Database Links Reactome: R-HSA-429947
Reactome: R-HSA-9820841
Reactome: R-HSA-9820865
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Polyadenylate-Binding Protein-Interacting Protein 1 antibody
Anti-Pabp-Interacting Protein 1 antibody
Anti-Paip-1 antibody
Anti-Poly(A-Binding Protein-Interacting Protein 1 antibody
Anti-PAIP1 antibody

Information sourced from Uniprot.org