| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PACSIN3 |
| Gene ID: | 29763 |
| Uniprot ID: | PACN3_HUMAN |
| Immunogen Region: | 175-424 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 175-424 of human PACSIN3 (NP_057307.2). |
| Immunogen Sequence: | KADSAVSQEQLRKLQERVER CAKEAEKTKAQYEQTLAELH RYTPRYMEDMEQAFETCQAA ERQRLLFFKDMLLTLHQHLD LSSSEKFHELHRDLHQGIEA ASDEEDLRWWRSTHGPGMAM NWPQFEEWSLDTQRTISRKE KGGRSPDEVTLTSIVPTRDG TAPPPQSPGSPGTGQDEEWS DEESPRKAATGVRVRALYDY AGQEADELSFRAGEELLKMS EEDEQGWCQGQLQSGRIGL |
| Tissue Specificity | Widely expressed, with highest levels in heart and skeletal muscle, intermediate levels in placenta, liver and pancreas, and very low levels in brain, lung and kidney. |
| Post Translational Modifications | Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). |
| Function | Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity. |
| Protein Name | Protein Kinase C And Casein Kinase Substrate In Neurons Protein 3Sh3 Domain-Containing Protein 6511 |
| Database Links | Reactome: R-HSA-8856828 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideDetected At The Inner Aspect Of The Plasma Membrane In Myotubes |
| Alternative Antibody Names | Anti-Protein Kinase C And Casein Kinase Substrate In Neurons Protein 3 antibodyAnti-Sh3 Domain-Containing Protein 6511 antibodyAnti-PACSIN3 antibody |
Information sourced from Uniprot.org