| Post Translational Modifications | Phosphorylated on Ser-202 and Ser-204 likely by CSNK2A1-CSNK2A2 serine/threonine-protein kinase complex. Activates 'Lys-63'-specific deubiquitinase activity. |
| Function | Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein. May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators. Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions. |
| Protein Name | Otu Domain-Containing Protein 4Hiv-1-Induced Protein Hin-1 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusPrimarily Cytoplasmic |
| Alternative Antibody Names | Anti-Otu Domain-Containing Protein 4 antibodyAnti-Hiv-1-Induced Protein Hin-1 antibodyAnti-OTUD4 antibodyAnti-HIN-1 antibodyAnti-KIAA1046 antibody |
Information sourced from Uniprot.org
