| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | OSTM1 |
| Gene ID: | 28962 |
| Uniprot ID: | OSTM1_HUMAN |
| Immunogen Region: | 32-284 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-284 of human OSTM1 (NP_054747.2). |
| Immunogen Sequence: | ALPFGSSPHRVFHDLLSEQQ LLEVEDLSLSLLQGGGLGPL SLPPDLPDLDPECRELLLDF ANSSAELTGCLVRSARPVRL CQTCYPLFQQVVSKMDNISR AAGNTSESQSCARSLLMADR MQIVVILSEFFNTTWQEANC ANCLTNNSEELSNSTVYFLN LFNHTLTCFEHNLQGNAHSL LQTKNYSEVCKNCREAYKTL SSLYSEMQKMNELENKAEPG THLCIDVEDAMNITRKLWS |
| Post Translational Modifications | Undergoes proteolytic cleavage in the luminal domain, the cleaved fragments might be linked by disulfide bonds with the remnant of the protein. Highly N-glycosylated. |
| Function | Required for osteoclast and melanocyte maturation and function. |
| Protein Name | Osteopetrosis-Associated Transmembrane Protein 1Chloride Channel 7 Beta Subunit |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type I Membrane ProteinRequires Clcn7 To Travel To Lysosomes |
| Alternative Antibody Names | Anti-Osteopetrosis-Associated Transmembrane Protein 1 antibodyAnti-Chloride Channel 7 Beta Subunit antibodyAnti-OSTM1 antibodyAnti-GL antibodyAnti-HSPC019 antibodyAnti-UNQ6098 antibodyAnti-PRO21201 antibody |
Information sourced from Uniprot.org