| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | OSM |
| Gene ID: | 5008 |
| Uniprot ID: | ONCM_HUMAN |
| Immunogen Region: | 26-252 |
| Immunogen Sequence: | AAIGSCSKEYRVLLGQLQKQ TDLMQDTSRLLDPYIRIQGL DVPKLREHCRERPGAFPSEE TLRGLGRRGFLQTLNATLGC VLHRLADLEQRLPKAQDLER SGLNIEDLEKLQMARPNILG LRNNIYCMAQLLDNSDTAEP TKAGRGASQPPTPTPASDAF QRKLEGCRFLHGYHRFMHSV GRVFSKWGESPNRSRRHSPH QALRKGVRRTRPSRKGKRLM TRGQLPR |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-252 of human Oncostatin M (NP_065391.1). |
| Post Translational Modifications | Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity. |
| Function | Growth regulator. Inhibits the proliferation of a number of tumor cell lines. Stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses both type I OSM receptor (heterodimers composed of LIFR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. |
| Protein Name | Oncostatin-MOsm |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-6788467 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Oncostatin-M antibodyAnti-Osm antibodyAnti-OSM antibody |
Information sourced from Uniprot.org
