| Host: | Rabbit |
| Applications: | WB/ICC/IF/IP |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-ORP1 (937-950 aa) is suitable for use in Western Blot, Immunocytochemistry, Immunofluorescence and Immunoprecipitation research applications. |
| Clonality : | Monoclonal |
| Clone ID : | R02-2E2 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Purification: | Affinity Purified |
| Concentration: | 0.3 mg/ml |
| Dilution Range: | WB 1:500-1:1000IF 1:50-1:200IP 1:20 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | OSBPL1A |
| Gene ID: | 114876 |
| Uniprot ID: | OSBL1_HUMAN |
| Immunogen Region: | 937-950 aa |
| Immunogen: | A synthetic peptide of human ORP1 |
| Function | Binds phospholipids.exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol. |
| Protein Name | Oxysterol-Binding Protein-Related Protein 1Orp-1Osbp-Related Protein 1 |
| Database Links | Reactome: R-HSA-192105Reactome: R-HSA-2132295 |
| Cellular Localisation | Late EndosomeColocalizes With Rab7aRab9a And Lamp1 In Late Endosomes |
| Alternative Antibody Names | Anti-Oxysterol-Binding Protein-Related Protein 1 antibodyAnti-Orp-1 antibodyAnti-Osbp-Related Protein 1 antibodyAnti-OSBPL1A antibodyAnti-ORP1 antibodyAnti-OSBP8 antibodyAnti-OSBPL1 antibodyAnti-OSBPL1B antibody |
Information sourced from Uniprot.org