| Tissue Specificity | Detected in the keratinocytes of the epidermis (at protein level). Detected in hair follicles in proximal outer root sheath and hair matrix keratinocytes (at protein level). |
| Function | Olfactory receptor. Activated by the synthetic sandalwood odorant sandalore. Endogenous ligand is unknown (Probable). The activity of this receptor is probably mediated by G proteins which induce elevation of intracellular Ca(2+), a cAMP-dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs. Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes. Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases. |
| Protein Name | Olfactory Receptor 2at4Olfactory Receptor Or11-265 |
| Database Links | Reactome: R-HSA-381753Reactome: R-HSA-9752946 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Olfactory Receptor 2at4 antibodyAnti-Olfactory Receptor Or11-265 antibodyAnti-OR2AT4 antibody |
Information sourced from Uniprot.org
