| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-OLIG2 (1-80) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
OLIG2 |
| Gene ID: |
10215 |
| Uniprot ID: |
OLIG2_HUMAN |
| Immunogen Region: |
1-80 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-80 of human Olig2 (NP_005797.1). |
| Immunogen Sequence: |
MDSDASLVSSRPSSPEPDDL FLPARSKGSSGSAFTGGTVS SSTPSDCPPELSAELRGAMG SAGAHPGDKLGGSGFKSSSS |
| Tissue Specificity | Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. |
| Function | Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. |
| Protein Name | Oligodendrocyte Transcription Factor 2Oligo2Class B Basic Helix-Loop-Helix Protein 1Bhlhb1Class E Basic Helix-Loop-Helix Protein 19Bhlhe19Protein Kinase C-Binding Protein 2Protein Kinase C-Binding Protein Rack17 |
| Cellular Localisation | NucleusCytoplasmThe Nls Contained In The Bhlh Domain Could Be Masked In The Native Form And Translocation To The Nucleus Could Be Mediated By Interaction Either With Class E Bhlh Partner Protein Or With Nkx2-2 |
| Alternative Antibody Names | Anti-Oligodendrocyte Transcription Factor 2 antibodyAnti-Oligo2 antibodyAnti-Class B Basic Helix-Loop-Helix Protein 1 antibodyAnti-Bhlhb1 antibodyAnti-Class E Basic Helix-Loop-Helix Protein 19 antibodyAnti-Bhlhe19 antibodyAnti-Protein Kinase C-Binding Protein 2 antibodyAnti-Protein Kinase C-Binding Protein Rack17 antibodyAnti-OLIG2 antibodyAnti-BHLHB1 antibodyAnti-BHLHE19 antibodyAnti-PRKCBP2 antibodyAnti-RACK17 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
