| Function | 2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC. Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST). Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids. Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate. Mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. |
| Protein Name | 2-Oxoglutarate Dehydrogenase Complex Component E1E1oHsogdhOgdc-E1Ogdh-E12-Oxoglutarate Dehydrogenase - MitochondrialAlpha-Ketoglutarate DehydrogenaseAlpha-Kgdh-E1Thiamine DiphosphateThdp-Dependent 2-Oxoglutarate Dehydrogenase |
| Database Links | Reactome: R-HSA-6783984Reactome: R-HSA-9837999Reactome: R-HSA-9853506 |
| Cellular Localisation | MitochondrionNucleusMainly Localizes In The MitochondrionA Small Fraction Localizes To The NucleusWhere The 2-Oxoglutarate Dehydrogenase Complex Is Required For Histone Succinylation |
| Alternative Antibody Names | Anti-2-Oxoglutarate Dehydrogenase Complex Component E1 antibodyAnti-E1o antibodyAnti-Hsogdh antibodyAnti-Ogdc-E1 antibodyAnti-Ogdh-E1 antibodyAnti-2-Oxoglutarate Dehydrogenase - Mitochondrial antibodyAnti-Alpha-Ketoglutarate Dehydrogenase antibodyAnti-Alpha-Kgdh-E1 antibodyAnti-Thiamine Diphosphate antibodyAnti-Thdp-Dependent 2-Oxoglutarate Dehydrogenase antibodyAnti-OGDH antibody |
Information sourced from Uniprot.org
![Anti-OGDH antibody (869-1023) [S4736RM] (STJ11104736)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/177380/369091/STJ11104736_1__20315.1713134577.jpg?c=1 "Anti-OGDH antibody (869-1023) [S4736RM] (STJ11104736)")
![Anti-OGDH antibody (869-1023) [S4736RM] (STJ11104736)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/177380/369091/STJ11104736_1__20315.1713134577.jpg?c=1 "Anti-OGDH antibody (869-1023) [S4736RM] (STJ11104736)")
