| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ODC1 |
| Gene ID: | 4953 |
| Uniprot ID: | DCOR_HUMAN |
| Immunogen Region: | 1-280 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ODC1 (NP_002530.1). |
| Immunogen Sequence: | MNNFGNEEFDCHFLDEGFTA KDILDQKINEVSSSDDKDAF YVADLGDILKKHLRWLKALP RVTPFYAVKCNDSKAIVKTL AATGTGFDCASKTEIQLVQS LGVPPERIIYANPCKQVSQI KYAANNGVQMMTFDSEVELM KVARAHPKAKLVLRIATDDS KAVCRLSVKFGATLRTSRLL LERAKELNIDVVGVSFHVGS GCTDPETFVQAISDARCVFD MGAEVGFSMYLLDIGGGFP |
| Post Translational Modifications | S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues. |
| Function | Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. |
| Protein Name | Ornithine DecarboxylaseOdc |
| Database Links | Reactome: R-HSA-350562Reactome: R-HSA-351202 |
| Alternative Antibody Names | Anti-Ornithine Decarboxylase antibodyAnti-Odc antibodyAnti-ODC1 antibody |
Information sourced from Uniprot.org