Anti-ODC1 antibody (1-280) (STJ24858)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ODC1 (1-280) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ODC1 |
| Gene ID | 4953 |
| Uniprot ID | DCOR_HUMAN |
| Immunogen Region | 1-280 |
| Immunogen Sequence | MNNFGNEEFDCHFLDEGFTA KDILDQKINEVSSSDDKDAF YVADLGDILKKHLRWLKALP RVTPFYAVKCNDSKAIVKTL AATGTGFDCASKTEIQLVQS LGVPPERIIYANPCKQVSQI KYAANNGVQMMTFDSEVELM KVARAHPKAKLVLRIATDDS KAVCRLSVKFGATLRTSRLL LERAKELNIDVVGVSFHVGS GCTDPETFVQAISDARCVFD MGAEVGFSMYLLDIGGGFP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ODC1 (NP_002530.1). |
Additional Info
| Post Translational Modifications | S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues. |
| Function | Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. |
| Protein Name | Ornithine DecarboxylaseOdc |
| Database Links | Reactome: R-HSA-350562Reactome: R-HSA-351202 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Ornithine Decarboxylase antibodyAnti-Odc antibodyAnti-ODC1 antibody |
Information sourced from Uniprot.org