| Post Translational Modifications | Autophosphorylated by protein kinase domains 1 and 2. |
| Function | Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle. Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1. Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). |
| Protein Name | ObscurinObscurin-RhogefObscurin-Myosin Light Chain KinaseObscurin-Mlck |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013406 |
| Cellular Localisation | Isoform 3: CytoplasmMyofibrilSarcomereM LineCytoplasmZ LineIn Differentiating Skeletal Muscle CellsIsoform 3 Primarily Localizes To The Sarcomeric M-Line And Less Frequently To The Z-DiskIsoform 3 Colocalizes With Ank1 Isoform Mu17/Ank15 At The M-Line In Differentiated Skeletal Muscle CellsCell MembraneSarcolemmaNucleusColocalizes With Cdh2 And Atp1b1 To The Sarcolemma And To Intercalating Disks In Cardiac MusclesColocalizes With Atp1b1 To M Line And Z Line In Cardiac Muscles |
| Alternative Antibody Names | Anti-Obscurin antibodyAnti-Obscurin-Rhogef antibodyAnti-Obscurin-Myosin Light Chain Kinase antibodyAnti-Obscurin-Mlck antibodyAnti-OBSCN antibodyAnti-KIAA1556 antibodyAnti-KIAA1639 antibody |
Information sourced from Uniprot.org
