Host: |
Goat |
Applications: |
Pep-ELISA/WB |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Goat polyclonal antibody anti-OAS3 (Internal) is suitable for use in ELISA and Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Concentration: |
0.5 mg/mL |
Dilution Range: |
WB-1-3µg/mlELISA-antibody detection limit dilution 1:64000. |
Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
Gene Symbol: |
OAS3 |
Gene ID: |
4940 |
Uniprot ID: |
OAS3_HUMAN |
Immunogen Region: |
Internal |
Accession Number: |
NP_006178.2 |
Immunogen Sequence: |
HPIQLDPNQKTPENS |
Function | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV). |
Protein Name | 2'-5'-Oligoadenylate Synthase 3(2-5'Oligo(A Synthase 32-5a Synthase 3P100 OasP100oas |
Database Links | Reactome: R-HSA-877300Reactome: R-HSA-8983711Reactome: R-HSA-909733 |
Cellular Localisation | CytoplasmNucleus |
Alternative Antibody Names | Anti-2'-5'-Oligoadenylate Synthase 3 antibodyAnti-(2-5'Oligo(A Synthase 3 antibodyAnti-2-5a Synthase 3 antibodyAnti-P100 Oas antibodyAnti-P100oas antibodyAnti-OAS3 antibodyAnti-P antibodyAnti-OKcl.4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance